One key consideration is the quality of information available from which more precise dosing recommendations can be constructed. Since we believe there are many examples where more precise dosing could benefit patients, it is worthwhile to consider how to prioritize drug–disease targets. Likewise, dosing is important where the drug can cause death or severe morbidity. Dosing is particularly important for diseases and/or drugs where the drug can decrease severe morbidity or prolong life. The administered dose of a drug modulates whether patients will experience optimal effectiveness, toxicity including death, or no effect at all.